Cannabinoid Encyclopedia

Health and effects

Cannabinoids and Nausea and vomiting

What studies can tell us about cannabinoids and Nausea and vomiting, including human research, early evidence, and important limits.

Updated July 2026 16 research sources Human research included

The short answer

What does the research say about Nausea and vomiting?

Researchers have studied cannabinoids in connection with Nausea and vomiting. The current literature covers THC, CBDA, and Cannabinoids in general. This page brings together 1 human-study source, 14 research reviews, and 1 lab, animal, or mechanism source. The source set includes human research as well as earlier-stage studies. There is no single answer that applies to every cannabinoid, dose, product, or person. 1

Choose your next step

Want the quick path or the full picture?

Use this guide the way you need to. Start with the practical question, then open the study detail only when it helps answer something about Nausea and vomiting.

What researchers studiedSee the main areas and the evidence behind each one. Safety and limitsKeep product, dose, medications, and context in view. Open the sourcesGo directly to the studies and references used here.

Key takeaways

What to know first

  1. 1

    Research on Nausea and vomiting covers THC, CBDA, and Cannabinoids in general; those areas should not be combined into one claim. 1

  2. 2

    The source set includes human research as well as earlier-stage studies. 2

  3. 3

    Dose, formulation, route, study population, and outcome can change how closely a study applies to a real-world question. 3

Research areas

What researchers studied about Nausea and vomiting

These are the main questions represented in the current literature. Each link opens a source used to build the overview.

Human research included

THC

Researchers have studied THC in connection with Nausea and vomiting. The exact compound, dose, formulation, sleep or health measure, and study design determine what the source can show. 2

Mostly mechanism-focused

CBDA

Researchers have studied CBDA in connection with Nausea and vomiting. The exact compound, dose, formulation, sleep or health measure, and study design determine what the source can show. 3

Too limited for a firm answer

Cannabinoids in general

Researchers have studied Cannabinoids in general in connection with Nausea and vomiting. The exact compound, dose, formulation, sleep or health measure, and study design determine what the source can show. 4

How strong is the research?

Not every study answers the same question

This page separates research in people, research reviews, and earlier-stage biology before interpreting the larger question.

1 source

Human studies

Research involving people is closest to everyday health questions. The product, dose, population, and outcome still determine what each study can show.

14 sources

Reviews and evidence summaries

Reviews can compare several studies at once. Their conclusion is only as strong and as relevant as the studies they include.

1 source

Lab, animal, and mechanism research

Early-stage research can explain biological interest. It cannot, by itself, show that the same effect happens in people.

What these studies actually looked at

The research on Nausea and vomiting is not one kind of study. This source set includes 11 narrative or expert reviews, 3 systematic reviews or meta-analyses, 1 animal study, and 1 clinical study in people. 3

The recorded populations or models include people or patients (12 sources), cells or tissue models (2 sources), and animal models (1 source). A result from one group or model should not be assumed to apply to another. 4

The most common recorded outcome focus is nausea, vomiting, or antiemetic outcomes (8 sources), cannabinoids and nausea or vomiting research outcomes (6 sources), and nausea-related or inflammation-related outcomes (3 sources). Closely related outcome names can still describe different measurements. 5

The Nausea and vomiting source set also contains findings or reviews that remain too limited, indirect, or mixed for a broad answer. That uncertainty is part of the result, not an empty space to fill with assumptions. 6

Examples from the literature

What did the studies actually look at?

Each example names the research question and the study details recorded for that source.

systematic review or meta-analysis

Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews.

On this page, this source examines Cannabinoids and cannabinoids and nausea or vomiting research outcomes. 1

Study type
systematic review or meta-analysis
Population or model
people or patients
Outcome focus
cannabinoids and nausea or vomiting research outcomes
Evidence stage
evidence still limited

narrative or expert review

Therapeutic Use of Cannabis and Cannabinoids: A Review.

On this page, this source examines THC and nausea and vomiting. 2

Study type
narrative or expert review
Population or model
pediatric, adolescent, or developmental context
Outcome focus
nausea, vomiting, or antiemetic outcomes
Evidence stage
evidence still limited

narrative or expert review

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer.

On this page, this source examines CBDA and nausea-related or inflammation-related outcomes. 3

Study type
narrative or expert review
Population or model
cells or tissue models
Outcome focus
nausea-related or inflammation-related outcomes
Evidence stage
evidence still limited

systematic review or meta-analysis

Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline.

On this page, this source examines Cannabinoids and cannabinoids and nausea or vomiting research outcomes. 4

Study type
systematic review or meta-analysis
Population or model
people or patients
Outcome focus
cannabinoids and nausea or vomiting research outcomes
Evidence stage
evidence still limited

systematic review or meta-analysis

Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.

On this page, this source examines THC and nausea and vomiting. 5

Study type
systematic review or meta-analysis
Population or model
people or patients
Outcome focus
nausea, vomiting, or antiemetic outcomes
Evidence stage
evidence still limited

Safety and limits

What should readers keep in mind?

Research on Nausea and vomiting should be read beside safety. A compound can be non-intoxicating or naturally occurring and still have pharmacologic effects, side effects, interactions, or product-quality concerns. 2

Research doses are descriptions of what a study tested. They are not personal dosing instructions. Questions involving medications, pregnancy, children, driving, liver health, heart health, or serious symptoms deserve professional medical guidance.

Drug interactions Pregnancy and children Driving and impairment All safety topics

Common questions

Questions people ask

Can cannabinoids help with Nausea and vomiting?

Research exists, but there is not one answer for every cannabinoid or product. The source set includes human research as well as earlier-stage studies. 7

Why can studies reach different answers?

Studies may test different cannabinoids, doses, formulations, routes, people, and outcomes. Those differences can change the result. 8

What should I check in a study?

Check whether it studied people, what product and dose it used, what it measured, how long it lasted, and whether safety was reported. 9

Sources

Read the research

The numbered sources below support the main overview. Links open the PubMed record or DOI in a new tab.

  1. 1
    Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews. systematic review or meta-analysis; evidence still limited PubMed 29168289 DOI 10.1002/ptr.5975
  2. 2
    Therapeutic Use of Cannabis and Cannabinoids: A Review. narrative or expert review; evidence still limited PubMed 41296368 DOI 10.1001/jama.2025.19433
  3. 3
    Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. narrative or expert review; evidence still limited PubMed 30627539 DOI 10.1155/2018/1691428
  4. 4
    Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline. systematic review or meta-analysis; evidence still limited PubMed 38478773 DOI 10.1200/jco.23.02596
  5. 5
    Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications. systematic review or meta-analysis; evidence still limited PubMed 35982439 DOI 10.1186/s12916-022-02459-1
  6. 6
    Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial. clinical study in people; human research PubMed 39151115 DOI 10.1200/jco.23.01836
  7. 7
    Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting. narrative or expert review; evidence still limited PubMed 27507945 DOI 10.3389/fphar.2016.00221
  8. 8
    Cannabinoids: the lows and the highs of chemotherapy-induced nausea and vomiting. narrative or expert review; evidence still limited PubMed 30720344 DOI 10.2217/fon-2018-0530
  9. 9
    Cannabinoids: Therapeutic Use in Clinical Practice. narrative or expert review; evidence still limited PubMed 35328765 DOI 10.3390/ijms23063344
  10. 10
    Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits. narrative or expert review; evidence still limited PubMed 39299947 DOI 10.1007/s00406-024-01880-2
  11. 11
    Chemotherapy-induced nausea and vomiting. narrative or expert review; evidence still limited PubMed 18391612 DOI 10.1097/ppo.0b013e31816a0f07
  12. 12
    Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics. narrative or expert review; evidence still limited PubMed 27274310 DOI 10.2147/cmar.s81425
See all 16 research sources

This complete source list is the deeper research layer for the page. Study type and evidence context are shown when they are available in the current record.

  1. Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. narrative or expert review; evidence still limited / 1 linked research note PubMed 30627539
  2. Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting. narrative or expert review; evidence still limited / 1 linked research note PubMed 34115951
  3. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. animal study; mechanism-focused research / 1 linked research note PubMed 23121618
  4. Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial. clinical study in people; human research / 2 linked research notes PubMed 39151115
  5. Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline. systematic review or meta-analysis; evidence still limited / 1 linked research note PubMed 38478773
  6. Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews. systematic review or meta-analysis; evidence still limited / 1 linked research note PubMed 29168289
  7. Regulation of nausea and vomiting by cannabinoids. narrative or expert review; evidence still limited / 1 linked research note PubMed 21175589
  8. Cannabinoids: the lows and the highs of chemotherapy-induced nausea and vomiting. narrative or expert review; evidence still limited / 1 linked research note PubMed 30720344
  9. Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting. narrative or expert review; evidence still limited / 1 linked research note PubMed 27507945
  10. Therapeutic Use of Cannabis and Cannabinoids: A Review. narrative or expert review; evidence still limited / 1 linked research note PubMed 41296368
  11. Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications. systematic review or meta-analysis; evidence still limited / 1 linked research note PubMed 35982439
  12. Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits. narrative or expert review; evidence still limited / 1 linked research note PubMed 39299947
  13. Cannabinoids: Therapeutic Use in Clinical Practice. narrative or expert review; evidence still limited / 1 linked research note PubMed 35328765
  14. Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics. narrative or expert review; evidence still limited / 1 linked research note PubMed 27274310
  15. The Risk of QTc Prolongation with Antiemetics in the Palliative Care Setting: A Narrative Review. narrative or expert review; evidence still limited / 1 linked research note PubMed 33974499
  16. Chemotherapy-induced nausea and vomiting. narrative or expert review; evidence still limited / 1 linked research note PubMed 18391612